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EFFECT OF CLINICAL DOSES OF FLUOXETINE ON PSYCHOLOGICAL
VARIABLES IN HEALTHY VOLUNTEERS

Y. Gelfin(1), M. Gorfine(2), B. Lerer(1)

(1) Biological Psychiatry Unit, Hadassah-Hebrew University Medical Center
(2) Department of Statistics, The Hebrew University of Jerusalem

February 1998

ABSTRACT

Objective: The authors sought to determine the effect of clinically equivalent doses of fluoxetine on mood and other psychological variables in normal subjects. Method: Fifteen healthy volunteers received placebo for 2 weeks; fluoxetine, 10 mg/day, for 1 week; fluoxetine, 20 mg/day, for 5 weeks; and
then an additional 2 weeks of placebo in the context of a single-blind study. The subjects were evaluated with a series of self- and observer-rated instruments. Results: No significant effects attributable to fluoxetine were observed on any of the psychological variables examined. Minimal adverse effects were reported. Conclusions: Significant mood-elevating and other psychological effects of fluoxetine would appeal to be induced only when symptomatic targets exist.

 

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